Author/Authors :
RAO P. SURESH C. نويسنده , Hegde Sanath Kumar نويسنده Radiation Oncology Department, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India , Baliga Manjeshwar Shrinath نويسنده Radiation Oncology Department, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India , Jayachander Dipika نويسنده Department of Radiation Oncology, Apollo Hospital, Bengaluru, Karnataka, India , Shivashankara Arnadi Ramachandrayya نويسنده Department of Biochemistry, Father Miller Medical College, Kankanady, Mangalore, India , Vidyasagar Mamidipudi Srinivasa نويسنده Department of Radiotherapy, Kasturba Medical College, Manipal University, Manipal, Karnataka, India , Tonse Raees نويسنده Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India , Pais Sarita نويسنده Department of Radiation Oncology, Narayana Hrudayalaya, Bengaluru, Karnataka, India , Lobo Ashwin DL نويسنده Department of Biochemistry, Father Miller Medical College, Kankanady, Mangalore, India
Abstract :
Background: This study evaluates the predictive significance of salivary amylase,
glutathione, lipid peroxides, and lactate dehydrogenase in the treatment of head and
neck cancer patients who undergo curative radiotherapy/chemoradiotherapy.
Methods: The volunteers for the study included head and neck cancer patients that
required curative radiotherapy/chemoradiotherapy. Patients provided saliva and blood
samples before the start of radiation treatment and 24 hours after the first radiation fraction
of 2 Gy (before the start of the second fraction). Samples were assessed for the levels
of blood and salivary amylase, glutathione, lipid peroxides, and lactate dehydrogenase
by standard laboratory methods. Clinical tumor radioresponse was assessed one month
after the completion of treatment as complete responders, partial responders, and
nonresponders.
Results: The results indicated a significant increase in the levels of amylase,
lactate dehydrogenase, and lipid peroxides; and a concomitant decrease in the levels
of glutathione P < 0.05 - P < 0.0001 in saliva and blood. The correlation between the
differences in each biochemical parameter with that of the treatment response showed
a significant correlation only for the salivary lactate dehydrogenase (R2=0.25; P < 0.02).
Conclusion: The results indicate that salivary lactate dehydrogenase can be a
useful predictive marker to ascertain radiation-induced tumor regression in head and
neck cancers.
