Author/Authors :
Khayamzadeh Maryam نويسنده Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , Nafissi Nahid نويسنده Breast Surgery Department, Iran University of Medical Sciences, Tehran, Iran , Zeinali Zahra نويسنده Medical Student, International Federation of Medical Students Associations, Tehran, Iran , Pazooki Davood نويسنده Breast Surgery Department, Iran University of Medical Sciences, Tehran, Iran , Hosseini Mostafa نويسنده Breast Surgery Department, Iran University of Medical Sciences, Tehran, Iran , Akbari Mohammad Esmaeil نويسنده Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Background: Breast cancer is the most prevalent cancer among females worldwide.
This study compares the results of the most cited published Iranian studies and studies
from other Middle East countries on breast cancer with data from the Ministry of Health
and Medical Education and approximately 2000 cases from the Cancer Research
Center of Shahid Beheshti Medical University of Iran.
Methods: Data from the Cancer Registry System of the Ministry of Health and
Medical Education and the Cancer Research Center were obtained in addition to data
from other published Iranian articles to increase the accuracy of incidence, prevalence,
disease burden, risk factors, clinical staging, clinical pathology, biological markers,
clinical subtypes, and survival rate of breast cancer in the last decade and compare the
epidemiological data with other areas of the world.
Results: Overall, breast cancer was the most common cancer in Iran. The agestandardized
rate for breast cancer was 33.21 per 100,000 according to the latest
national databases. The mortality rate for breast cancer has not changed in the past 30
years in Iran. The age-standardized rate for mortality was 14.2 per 100,000 with a mean
age of 49.84 years. The most common cancer in Iran is invasive ductal carcinoma. In
our last review, 65.5%-70.5% of cases were in the early stages (1 and 2) and less than
30% were in the advanced stages. The five-year overall survival rate was estimated at
72% in women and 60% in men. The stage and number of positive lymph nodes
significantly affected the survival rate.
In the Gulf Cooperation Council, ASR of the Kingdom of Saudi Arabia was (12.9),
Bahrain (46.4), Kuwait (44.3), Qatar (35.5), United Arab Emirates (19.2), and Oman
(14.4) per 100,000.
Conclusion: Our study shows that epidemiology and histopathology of cancer is
different with other neighborhood countries and is multi-dimension and needs multicenter
involvement from government authorities, clinicians and scientists.
