Successful Treatment of Acute Hepatitis C Virus (HCV) Infection with Interferon-Free Regimen in a Renal Transplant Patient: The First Case Report

[Introduction]Hepatitis C virus (HCV) is considered a major public health problem and in the organ transplant subjects, particularly. The classical interferon/ribavirin regimen is unadvisable for renal transplant patients due to intolerability and adverse effects.[Case Presentation]Here, the first case of successful treatment of acute HCV in renal transplant patient is described. A 24-week course of sofosbuvir plus ribavirin was given to a 41- year-old male patient with renal transplant who was diagnosed with acute HCV. The patient was treated successfully without major side effects and without undesirable interaction with immunosuppressive medications.[Conclusions]This is the first case report regarding the treatment of acute HCV in renal transplant subject using sofosbuvir-containing regimen. More studies are needed to investigate the treatment of acute HCV with the use of new medications especially in the organ transplant subjects.