Author/Authors :
Kabir Soodeh نويسنده Department of Dermatology, Guilan University of Medical Sciences, Rasht, IR Iran , Schmults Chrysalyne D. نويسنده Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA , Ruiz Emily S. نويسنده Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
Abstract :
[Context]Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer and its incidence continues to rise worldwide. While the majority of CSCCs have excellent prognosis, a subset have the propensity to cause poor outcomes.[Evidence Acquisition]A thorough Pubmed search was done and a collection of CSCC-relevant articles were selected based on the expert opinion.[Results]A number of high-risk factors have been identified including perineural invasion (PNI), desmoplastic growth pattern, poor differentiation, high risk location and large diameter. Various staging systems have been developed based on these high-risk factors. Radiologic imaging is important for high-stage tumors and is likely associated with more aggressive management.[Conclusions]Although surgical management is the gold standard, newer therapies such as programmed cell death protein-1 (PD-1) inhibitors show promise for locally advanced or metastatic disease. Despite advances in treatment, early diagnosis and prevention of CSCC is still the most important measure to ensure good outcomes.
