Author/Authors :
Mohammadi Saeed نويسنده Faculty of Advanced Medical Technology, Golestan University of Medical Sciences, Gorgan, IR Iran Mohammadi Saeed , Malmir Somaye نويسنده Department of Physics, Payame Noor University, Tehran, Iran , Asghar Mowlavi Ali نويسنده Hakim Sabzevari University, Department of Physics, School of Sciences, Sabzevar, Iran
Abstract :
[Background]Numerous qualitative studies have been carried out on the safety and clinical use of GNPs as a radio-sensitizer in tumors, using proton therapy and the results have been promising. However, some quantitative studies should be conducted in order to examine the factors affecting this method.[Methods]Monte Carlo simulation was performed by MCNPX code to assess pristine Bragg peak, spread-out bragg peak (SOBP), and secondary particle production enhancement in GNPs radio-sensitized tumor using proton therapy.[Results]The results show several percent dose enhancement within and its reduction after the tumor site. A little increase in neutron production and no deviation for photon production is indicated.[Conclusions]Finally, it can be concluded that sensitization of a realistic tumor can be beneficial during the proton therapy.
