Title of article :
Time-Dependent Changes in the Magnetic Resonance Detection of Brain Metastases Using Single-Dose Gadobutrol
Author/Authors :
Jiang Ke Jian نويسنده , Wang Xiao-Ying نويسنده , Fan Bing نويسنده Department of Radiology, Yichang Yiling Hospital, Yichang, China , Li Mei-jiao نويسنده Department of Radiology, Peking University First Hospital, Beijing, China , Xu Yu-feng نويسنده Department of Radiology, Peking University First Hospital, Beijing, China , Li Fei-yu نويسنده Department of Radiology, Peking University First Hospital, Beijing, China , Zhang Lai-yun نويسنده Department of Radiology, Peking University First Hospital, Beijing, China , Jiang Yan-yan نويسنده Department of Radiology, Peking University First Hospital, Beijing, China
Pages :
7
From page :
1
To page :
7
Abstract :
[Objectives]The effect of delay in imaging on the assessment of contrast-enhanced magnetic resonance imaging (CE-MRI) has not been extensively studied. This study evaluated the effect of different delay times (3, 7, and 10 minutes) on gadobutrol (Gadovist)-enhanced MRI for diagnosis of brain metastases.[Patients and Methods]This single-center, blind-reading, post-marketing study enrolled 52 patients with suspected or known brain metastases who received gadolinium-enhanced MR examinations. All the patients received 0.1 mmol/kg dose of gadobutrol, and serial axial T1 FLAIR images were obtained at each MR examination after a delay of 3, 7, and 10 minutes. The images were evaluated by two experienced radiologists independently. The evaluation included subjective and objective evaluations of the image quality.[Results]Thirty-four patients were diagnosed with brain metastases. There were 295, 301, and 301 lesions detected in the 3, 7, and 10 minutes delay groups, respectively. Subjective evaluation revealed a higher mean quality score of lesion edge, lesion interior, and overall image quality in the 7 and 10 minutes groups compared to the 3 minutes group. Images in the 7- or 10-min delay groups had significantly greater CNR and CBR than the 3-min group (P < 0.05).[Conclusion]A delay time of 7 minutes was considered optimal for imaging after gadobutrol administration in patients with brain metastases.
Journal title :
Astroparticle Physics
Serial Year :
2018
Record number :
2411231
Link To Document :
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