Author/Authors :
Choobineh Hamid نويسنده School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran , Alaei Sheini Farzaneh نويسنده 1Department of Biology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. , Tabnak Malihe نويسنده 2Department of Basic Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran. , Hasanzadeh Bezvan Maryam نويسنده 3Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran. , Mahdiannasser Mojdeh نويسنده 4Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. , Musavi Hadis نويسنده 5Department of Biochemistry, Faculty of Basic Sciences, Razi University, Kermanshah, Iran. , Abbasi Mojtaba نويسنده 7Veterinary Medicine, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
Abstract :
Cytomegalovirus (CMV) is a species of Herpesviridae showing no clinical symptoms in the earlier stage of infection in pregnant women. Nevertheless, it can be transmitted to the baby through saliva, body fluids, blood and cervical secretions. The aim of this study is a systematic review of the effects of CMV on abortion. Data were collected from Web of Science (ISI), PubMed, Scopus, Ovid, and EMBASE databases published by May 2018. The keywords used included abortion, current abortion, B19, Cytomegalovirus, spontaneous abortion, and placenta. The National Institutes of Healthʹs Quality Assessment Tool was used for quality assessment. Fifteen papers from 1993 to 2018 were reviewed 11 of which were descriptive-analytic and the remaining 6 were case-control. In the case-control studies, the control group consisted of healthy pregnant women with no history of abortion. The case group comprised women who had experienced abortion and recurrent abortion. The maximum sample size included 779 and the minimum included 17 cases of abortion. The highest incidence of CMV infection in abortion was 100% reported by Saraswathy and 97% in the study of Tarokhian. The lowest was observed by Oliveira with 0.04% and by Kakru with 16%.The results of most studies indicate that CMV infection can lead to abortion by transfer through body fluids activation of the uterine inflammatory
