Author/Authors :
Safaralizadeh Reza نويسنده Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran , HosseinpourFeizi Mohammad Ali نويسنده Faculty of Natural Sciences,Department of Biology,University of Tabriz,Tabriz,Iran , Faramarzi Arezoo نويسنده 1Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. , Moaddab Yaghoub نويسنده 2Liver and Gastroenterology Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract :
Background and Aims: An impairment of expression in MLL2 gene involved in histone methylation induces alteration in the methylation patterns at enhancers and causes several cancers including colon cancer. In this study, MLL2 expression was evaluated in North West of Iran.
Materials and Methods: To evaluate the MLL2 expression in patients with colon cancer, 25 tumor samples and 25 samples of tumor margins were collected and analyzed by real-time polymerase chain reaction.
Results: KMT2B level was not associated with age (p=0.3), gender (p=0.05) and tumor size (p=0.2) but had relation with stage of tumor (p=0.04).
Conclusions: According to the results obtained from investigating
the MLL2 gene expression, it was found that it has a significant relationship with the stage of tumor.
