Title of article :
Epidemiology and Molecular Detection of HAV, HBV, and HCV in Patients with Acute Hepatitis Symptoms in Ahvaz
Author/Authors :
Makvandi Manoochehr نويسنده , Pirmoradi Roya نويسنده , Moradzadegan Hamid نويسنده Jundishapur Infectious and Tropical Diseases Research Center, Jundishapur University of Medical Sciences, Ahvaz, IR Iran , Karami Chiman نويسنده Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, IR Iran , Teimoori Ali نويسنده Department of Virology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , Tabasi Maryam نويسنده School of Public Health, Tehran University of Medical Sciences. , Dastoorpoor Maryam نويسنده Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, IR Iran , Parsanahad Mahdi نويسنده Department of Virology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract :
[Background]Viral hepatitis has emerged as a major public health problem leading to disproportionate degrees of morbidity and mortality worldwide.[Objectives]This study describes epidemiology of hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV), and associated risk factors in patients with acute hepatitis symptoms in southwest of Iran (Ahvaz).[Methods]A total of 150 serum samples from patients with elevated serum aminotransferase levels were subjected to serological and molecular assays.[Results]The sero-prevalence of HAV, HBV, and HCV was 79.3%. Furthermore, HAV, HBV, and HCV nucleic acids were detected in 28%, 18.7%, and 22.7% of samples, respectively. All HAV cases were categorized in the IB genotype and HBV isolates belonged to genotype D. Hepatitis C virus RNA-positive samples were clustered in genotypes 1a (38.3%) and 3a (61.7%). The authors found that some risk factors, such tattooing and traveling to endemic areas, had a crucial role in rising of viral hepatitis frequency in Ahvaz city.[Conclusions]These results document the prevalence of circulating viral hepatitis in Ahvaz city and may draw attention to the necessity for a comprehensive program to control viral hepatitis in this region.
