Author/Authors :
Ikemoto Tatsunori نويسنده Multidisciplinary Pain Centre, School of Medicine, Aichi
Medical University, Aichi, Japan , Arai Young-Chang نويسنده Multidisciplinary Pain Centre, School of Medicine, Aichi
Medical University, Aichi, Japan , Shimo Kazuhiro نويسنده Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan. , Nishihara Makoto نويسنده Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan. , Ushida Takahiro نويسنده Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan. , Shiro Yukiko نويسنده Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan , Funak Yasushi نويسنده Department of Gastroenterology, School of Medicine, Aichi Medical University, Nagakute, Japan , Kasugaii Kunio نويسنده Department of Gastroenterology, School of Medicine, Aichi Medical University, Nagakute, Japan , Omichi Yusuke نويسنده Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan , Sakurai Hiroki نويسنده Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan , Matsubara Takako نويسنده Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan , Inoue Masayuki نويسنده Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan , Saisu Hironori نويسنده Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan , Owari Keiko نويسنده Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan
Abstract :
[Background]Bacteria can influence a variety of gut functions. Some studies showed that stool consistency and constipation were associated with gut microbiome (GM) composition, and enterotype, dysbiosis. Growing evidence indicates the significant role of GM in the homeostatic function of the host body. The GM may regulate multiple neurochemical and neurometabolic pathways. Chronicity of the pain is actively modulated at the molecular to the network level by means of several neurotransmitters. The GM to some extent can affect pain perception.[Objectives]The current study aimed at investigating the relationship between constipation state or usual stool form and pain severity of patients with chronic pain.[Methods]The current study was conducted on 365 patients with chronic pain. The participants were evaluated on their stool form (the Bristol stool form scale; BSFS), constipation state (the Cleveland clinic constipation score; CCCS), body mass index (BMI), and usual pain severity (numerical rating scale; NRS). In addition, the participants were assigned into five groups according to the pain region (i e, low back and/or lower limb, whole body, neck and/or upper back and/or upper limb, head and/or face, chest and/or abdominal).[Results]The CCS showed a significant and positive association with the pain severity of the total patients and patients with low back and/or lower limb pain. Simultaneous multiple linear regression analyses revealed that a predictor of the pain severity was the CCS for the total patients and patients with low back and/or lower limb, whole body pain.[Conclusions]Constipation displayed a significant and positive association with the pain severity of the total patients and patients with low back and/or lower limb pain, whole body.
