Author/Authors :
Heshmat Ramin نويسنده , Kelishadi Roya نويسنده , Haghjooy Javanmard Shaghayegh نويسنده Physiology Research Center , Mansourian Marjan نويسنده Department of Biostatistics, Isfahan University of Medical Sciences, Isfahan , Marateb Hamid Reza نويسنده Departments of Biomedical Engineering Faculty of Engineering, University of Isfahan, Hezar Jerib Street, Isfahan, Iran , Esmaeil Motlagh Mohammad نويسنده Department of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , Moghadasi Mehri نويسنده Student Research Center, Biostatistics and Epidemiology Department, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract :
[Background]To investigate the associations of genetic polymorphism with high-density lipoprotein-cholesterol (HDL-C) levels in Iranian adolescents.[Methods]This multicentre study was conducted on 10 - 18 year-old students from 27 provinces in Iran. Logic regression approach was used to determine the main effects and interactions of polymorphisms related to HDL-C levels.[Results]The rs708272 polymorphism was significantly related to HDL-C levels. Moreover, rs708272 increased HDL-C levels and had a protective effect on HDL-C. The interaction of rs2230808 and rs5880 polymorphisms as well as the interaction of rs320 and rs708272 polymorphisms were associated with lower HDL-C levels. Furthermore, the interaction of rs320 and rs1801177 polymorphisms was associated with lower HDL-C levels.[Conclusions]We found that not only single SNPs, but also interactions of several SNPs affect HDL-C levels. Given the high prevalence of low HDL-C in Middle Eastern populations, further genetic studies are required for detailed analysis.
