Author/Authors :
Vivas-Rosales Irving Jesus نويسنده Department of Pediatric, Pediatrics Hospital, National Medical Center (The Siglo XXI), Mexican Institute of Social Security , Garcia-Saavedra Liliana نويسنده Department of Physical Medicine and Rehabilitation, Pediatrics Hospital, National Medical Center (The Siglo XXI), Mexican Institute of Social Security , Martin-Trejo Jorge Alfonso نويسنده Department of Hematology, Pediatrics Hospital, National Medical Center (The Siglo XXI), Mexican Institute of Social Security , Mejia-Arangure Juan Manuel نويسنده Division of Evaluation of Research, Health Research Coordination, Mexican Institute of Social Security , Victorio-Garcia Nora Patricia نويسنده Faculty of Medicine of Tampico “Dr. Alberto Romo Caballero”, Autonomous University of Tamaulipas , Herrera-Landero Alejandro نويسنده Traumatology and Orthopedics Hospital “Lomas Verdes” Mexican Institute of Social Security , Núñez-Enríquez Juan Carlos نويسنده Clinical Epidemiology Research Department, Pediatrics Hospital, National Medical Center (The Siglo XXI), Mexican Institute of Social Security
Abstract :
[Background]Chemotherapy-induced peripheral neuropathy (CIPN) is frequent in children with acute lymphoblastic leukemia (ALL). Neurological manifestations can be grouped into one of the three functional divisions of the peripheral nervous system (PNS): sensory, motor and autonomic. One of the chemotherapeutic agents used in ALL is vincristine which has been associated with neuropathy in these children. This type of neuropathy can be transient but also leave permanent sequels that decrease patient’s quality of life.[Objectives]To know the frequency and type of neuropathy induced by chemotherapy in a subpopulation of Mexican pediatric patients with acute lymphoblastic leukemia.[Methods]A cross-sectional study was conducted. There were included all pediatric patients with ALL diagnosed de novo from 2010 to December 31, 2013 who met the selection criteria. Descriptive statistics were used to determine the frequency and type of CIPN and information was described according to different clinical variables, type of treatment, risk classification, and ALL subtype according to the immunophenotype.[Results]A total of 32 patients with acute lymphoblastic leukemia were included, mainly of early pre-B immunophenotype (93.8%), being 59.4% classified as high risk patients at the time of diagnosis. CIPN of sensory type was 78.1%, motor 34.3% and autonomic 40.6%. A significant proportion of patients (46.9%) were examined during maintenance phase.[Conclusions]To our knowledge, this is the first study to report the frequency and type of CIPN in a subpopulation of Mexican children with acute lymphoblastic leukemia. Frequency of CIPN was higher than that reported in other populations. By considering that prognosis of a patient presenting CIPN could be considered as favorable after treatment suspension (in most cases), it is not always reversible and affects patient’s quality of life. Therefore, it is necessary for all patients with ALL to be periodically monitored during treatment through neurological examination for detecting and immediately initiating their rehabilitation treatment.
