Author/Authors :
صادقی محمدرضا نويسنده , Khorram Khorshid Hamidreza نويسنده Genetic Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. , Darbandi Sara نويسنده Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran , Darbandi Mahsa نويسنده Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran , Shirazi Abolfaz نويسنده Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran , Agarwal Ashok نويسنده Center for Reproductive Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA. , Al-Hasani Safaa نويسنده Reproductive Medicine Unit, University of Schleswig-Holstein, Luebeck, Germany , Naderi Mohammad Mehdi نويسنده Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran , Ayaz Ahmet نويسنده Yildiz Technical University, Istanbul, Turkey , Akhondi Mohammad Mehdi نويسنده Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
Abstract :
Nuclear transfer procedures have been recently applied for clinical and research targets as a novel assisted reproductive technique and were used for increasing the oocyte activity during its growth and maturation. In this review, we summarized the nuclear transfer technique for germinal vesicle stage oocytes to reconstruct the maturation of them. Our study covered publications between 1966 and August 2017. In result utilized germinal vesicle transfer techniques, fusion, and fertilization survival rate on five different mammalian species are discussed, regarding their potential clinical application. It seems that with a study on this method, there is real hope for effective treatments of old oocytes or oocytes containing mitochondrial problems in the near future.
