Author/Authors :
Riad M . نويسنده Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt , Rezk R . نويسنده Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt , Ahmed Kholoud نويسنده Pharmaceutical and Analytical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts, 6th of October city, Egypt , Salem Hesham نويسنده Pharmaceutical and Analytical Chemistry Department, Faculty of Pharmacy, Deraya University, Egypt
Abstract :
The construction and electrochemical response characteristics of three selective
electrodes were investigated using precipitation based technique with phosphotungstate and
phosphomolybdate; respectively upon using polyvinyl chloride (PVC) matrix and dioctyl
phthalate (DOP) as a plasticizer. The resultant membrane sensors were tinidazole
phosphotungestate (TND-PTA) electrode (sensors 1), tinidazole phosphomolybdate (TNDPMA)
electrode (sensors 2) and clarithromycin phosphotungestate (CLR-PTA) electrode
(sensors 3). Linear responses of TND and CLR within the concentration ranges of 10?6 to
10?2 mol/L for sensors 1, 2 and 3 were observed. Nernstian slopes of 58.3, 57.1 and 58.8
mV/decade were observed over the pH range of 3-7 for sensors 1and 2 and over range of 3-8
for sensor 3, respectively. The selectivity coefficients of the developed sensors indicated
excellent selectivity for TND and CLR. The proposed sensors displayed useful analytical
characteristics for the determination of TND and CLR in bulk powder and pharmaceutical
formulation (Helicure® tablets)
