Author/Authors :
Bagoji Atmanand M . نويسنده P. G. Department of studies in chemistry, Karnatak University, Dharwad-580003, India , Gokavi Naveen M . نويسنده P. G. Department of studies in chemistry, Karnatak University, Dharwad-580003, India , Pattar Vijay P . نويسنده P. G. Department of studies in chemistry,Karnatak University, Dharwad-580003, India , Nandibewoor Sharanappa T . نويسنده P. G. Department of studies in chemistry, Karnatak University, Dharwad-580003, India
Abstract :
A new carbon paste electrode modified with NiSO4 (NSCPE) was fabricated and employed in electrocatalytic oxidation of 2-thiouracil (2-TU) for the first time using cyclic voltammetry (CV), square wave voltammetry (SWV) and differential pulse voltammetry (DPV) as diagnostic techniques. Characterization of the NSCPE was carried out by CV and scanning electron microscope (SEM) techniques. All experimental parameters have been optimized. The plausible mechanism of oxidation of 2-TU was proposed. The DPV of 2-TU gave a good linear response in the range of 10-100×10-8M with a limit of detection 2.1×10-9 M and limit of quantification 6.9×10-9M. The proposed method was successfully applied for quantitative determination of 2-TU in pharmaceutical formulations and urine as real sample
