The Effects of Endurance Training with Genistein on ICAM-1, VCAM-1, and CRP of Diabetic Rats

Objective: The purpose of this study was to investigate the effects of endurance training accompany with taking genistein on Intercellular Adhesion Molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and C-reactive protein (CRP) levels in diabetic rats. Materials and Methods: Sixty-four rats were divided into eight groups (1; healthy &sacrificed  at the first week, 2; healthy &sacrificed  at the last week, 3; diabetic &sacrificed  at the first week, 4; diabetic &sacrificed  at the last week, 5; endurance training, 6; taking genistein, 7; endurance training with taking genistein, and 8; placebo). The training groups were participated in three week sessionsof running on animal treadmill with span of 60 min and intensity range from 17 to 28 (m/s), during eight weeks. In addition, the genistein groups took daily amounts of 30 (mg/kg), through Intraperitoneal injection. In order to analyze data, one-way ANOVA and Toki post-hoc test were implemented (P≤0.05). Results: The results showed that induction of diabetes would lead to increases in ICAM-1, VACAm-1, and CRP levels, among the rats. Though, all the three of endurance training, taking genistein and endurance training with taking genistein would cause significant reductions in the increased levels of ICAM-1 and CRP (P<0.05). Nevertheless, those mentioned three could not significantly decrease the increased level of VCAM-1, in the statistical aspect (P>0.05). Moreover, there was no significant difference between the effects of the three endurance training, taking genistein, and endurance training with taking genistein (P>0.05). Conclusion: Eight weeks endurance training and also taking genistein do own improving influences on Inflammatory and cardiovascular risk factors among diabetic rats. Though, their combination does not have any synergistic effect.