Title of article
Studies of Cytotoxic Potential of Cucumis melo. Linn Fruit Aqueous Extract in Prostate Cancer Cell lines PC-3 Using MTT and Neutral Red Assay
Author/Authors
Perumbamkudiyil Ittiyavirah, Sibi Department of Pharmacology - University College of Pharmacy, Cheruvandoor campus, Kottayam, India , George, Ann Department of Pharmacology - University College of Pharmacy, Cheruvandoor campus, Kottayam, India , Santhosh, Anju M Department of Pharmacology - University College of Pharmacy, Cheruvandoor campus, Kottayam, India , Kurian, Sudhi T Department of Pharmacology - University College of Pharmacy, Cheruvandoor campus, Kottayam, India , Pappachan, Prinsy Department of Pharmacology - University College of Pharmacy, Cheruvandoor campus, Kottayam, India , Jacob, Gifty Department of Pharmacology - University College of Pharmacy, Cheruvandoor campus, Kottayam, India
Pages
6
From page
24
To page
29
Abstract
The objective of the study was to evaluate thecytotoxic effects of aqueous fruit extract of Cucumis melo in human prostate cancer cell line (PC-3) using MTTand neutral red assays. The crude aqueous extract of C.melo was prepared by cold maceration method، filtered،concentrated and tested on PC-3 cell line. Dose-dependent cytotoxic activitieswere exhibited by human prostate carcinoma PC-3 cell line. As the dose of theextract increased، the number of viable cells decreased. This confirms the anti-cancerand cytotoxic potential of the fruit of C.melo.
Keywords
Cytotoxicity , MTT assay , Neutral red assay , Human prostate carcinoma cell lines (PC-3) , Cucumis melo
Journal title
Astroparticle Physics
Serial Year
2013
Record number
2414124
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