Author/Authors :
Perumbamkudiyil Ittiyavirah, Sibi Department of Pharmacology - University College of Pharmacy, Cheruvandoor campus, Kottayam, India , George, Ann Department of Pharmacology - University College of Pharmacy, Cheruvandoor campus, Kottayam, India , Santhosh, Anju M Department of Pharmacology - University College of Pharmacy, Cheruvandoor campus, Kottayam, India , Kurian, Sudhi T Department of Pharmacology - University College of Pharmacy, Cheruvandoor campus, Kottayam, India , Pappachan, Prinsy Department of Pharmacology - University College of Pharmacy, Cheruvandoor campus, Kottayam, India , Jacob, Gifty Department of Pharmacology - University College of Pharmacy, Cheruvandoor campus, Kottayam, India
Abstract :
The objective of the study was to evaluate thecytotoxic effects of aqueous fruit extract of Cucumis melo in human prostate cancer cell line (PC-3) using MTTand neutral red assays. The crude aqueous extract of C.melo was prepared by cold maceration method، filtered،concentrated and tested on PC-3 cell line. Dose-dependent cytotoxic activitieswere exhibited by human prostate carcinoma PC-3 cell line. As the dose of theextract increased، the number of viable cells decreased. This confirms the anti-cancerand cytotoxic potential of the fruit of C.melo.
Keywords :
Cytotoxicity , MTT assay , Neutral red assay , Human prostate carcinoma cell lines (PC-3) , Cucumis melo
