Author/Authors :
Butchi Akondi, Raju Department of Pharmacology - College of Pharmaceutical Sciences - Andhra University - Visakhapatnam, A.P, 530003, India , Kumar, Phani Department of Pharmacology - College of Pharmaceutical Sciences - Andhra University - Visakhapatnam, A.P, 530003, India , Annapurna, Akula Department of Pharmacology - College of Pharmaceutical Sciences - Andhra University - Visakhapatnam, A.P, 530003, India , Pujari, Manasa Department of Pharmacology - College of Pharmaceutical Sciences - Andhra University - Visakhapatnam, A.P, 530003, India
Abstract :
Oxidative stress is one of the important causes of the type 1 diabetes induced changes in the sperm quality. Bioflavonoids, Rutin 10 mg/Kg and Naringin 10 mg/Kg were evaluated for their protective effects on sperm parameters, oxidative stress, and histopathology of type 1 diabetic rats. Results demonstrated the reduction in sperm count, sperm motility and vitality in diabetic rats. Mass drug administration (MDA) levels were increased and superoxide dismutase (SOD) catalase levels were decreased. Histopathological changes were evident and in accordance with the above results. In the treatment groups, both Rutin and Naringin in combination with insulin treatment in diabetic rats produced protection from diabetes and improved all the sperm parameters, decreased the MDA levels and increased the SOD and catalase levels. Protection was evident in histological examination. Our data suggests that the possible protection of testicular tissue and reproduction from oxidative stress have been induced by type 1 diabetes mellitus.
Keywords :
Type 1 diabetes , Oxidative stress , Male infertility , Rutin , Naringin
