Title of article :
Hepatoprotective Effect of Otostegia persica Boiss. Shoot Extract on Carbon Tetrachloride-Induced Acute Liver Damage in Rats
Author/Authors :
Nasiri Bezenjani, Sedighe Department of Biology - School of Sciences - Shahid Bahonar University of Kerman , Pouraboli, Iran Department of Biology - School of Sciences - Shahid Bahonar University of Kerman , Malekpour Afshar, Reza Research Center of Physiology - Kerman University of Medical Sciences , Mohammadi, Gholamabbas Department of Biochemistry - Medical School of Afzalipour - Kerman University of Medical Sciences
Abstract :
In this study, the hepatoprotective effect of the methanol extract of aerial parts (shoot) from Otostegia persica Boiss (Golder) was investigated against the carbon tetrachloride (CCl4)-induced acute hepatotoxicity in male rats. Liver damage was induced through the oral administration of 50% CCl4 in liquid paraffin (2.5 mL/Kg bw, per os) 60 min after the administration of the methanol extract of O. persica shoot (in 200, 300, 400 mg/Kg bw doses) and assessed using biochemical parameters (plasma and liver tissue malondialdehyde (MDA), transaminase enzyme levels in plasma [aspartate transaminase (AST), alanine aminotransferase (ALT)] and liver glutathione (GSH) levels). Results show that the methanol extract of O. persica shoot is active at 300 mg/Kg (per os) and it possess remarkable antioxidant and hepatoprotective activities. Additionally, histopathological studies verified the effectiveness of
this dose of extract in acute liver damage prevention.
Keywords :
Otostegia persica , Hepatoprotective , Carbon tetrachloride , Histopathology , MDA , GSH
Journal title :
Astroparticle Physics
