Author/Authors :
Aliabadi, Alireza Department of Medicinal Chemistry - Faculty of Pharmacy - Kermanshah University of Medical Sciences, Kermanshah , Andisheh, Sajad Department of Medicinal Chemistry - Faculty of Pharmacy - Kermanshah University of Medical Sciences, Kermanshah - Students Research Committee - Kermanshah University of Medical Sciences, Kermanshah , Tayarani-Najaran, Zahra Department of Pharmacodynamics and Toxicology - School of Pharmacy - Mashhad University of Medical Sciences , Tayarani-Najaran, Mona Departmrnt of Chemistry - Alzahra University, Tehran
Abstract :
Cancer is a major global problem and is the second leading cause of mortality in the
developed countries.Resistance to current chemotherapeutics and high incidence of adverse effects are the two principal reasons for developing new anticancer agents. Phenylacetamide derivatives can act as potential anticancer agents. Synthesis and screening of 2-(4-Fluorophenyl)- N-phenylacetamide derivatives in present study showed that these compounds act as potent anticancer agents especially against PC3(prostate carcinoma) cell line. Compounds 2a-2c with nitro moiety demonstrated a higher cytotoxic effect than compounds 2d-2f with methoxy moiety. All compounds in this series exhibited lower activity than imatinib as reference drug. Compounds 2b (IC50 = 52 μM) and 2c (IC50 = 80 μM) were the most active compounds against
PC3 cell line in comparison with imatinib(IC50 = 40 μM). Compound 2c (IC50 = 100 μM) with p-nitro substituent was the most active compound compared to imatinib(IC50 = 98 μM) in MCF-7 cell line.
Keywords :
Synthesis , Phenylacetamide derivatives , Anticancer , Cytotoxicity , MTS assay
