Author/Authors :
Nassiri, Nariman Jules Stein Eye Institute - David Geffen School of Medicine - University of California Los Angeles, Los Angeles, CA, USA , Mehravaran, Shiva Jules Stein Eye Institute - David Geffen School of Medicine - University of California Los Angeles, Los Angeles, CA, USA , Eslani, Medi Department of Ophthalmology & Visual Sciences - University of Illinois at Chicago, Chicago, IL, USA , Djalilian, Ali R. Department of Ophthalmology & Visual Sciences - University of Illinois at Chicago, Chicago, IL, USA , Panahi, Nekoo 3Eye Research Center - Farabi Eye Hospital - Tehran University of Medical Sciences, Tehran, Iran , Ziaei, Alireza Schepens Eye Research Institute - Massachusetts Eye and Ear Infirmary - Harvard Medical School, Boston, MA, USA
Abstract :
Graft versus host disease (GVHD) is a common complication of allogeneic stem
cell transplantation (allo-SCT). Ocular GVHD develops in approximately 40–60%
of patients following allo-SCT and its most common clinical manifestations include
keratoconjunctivitis sicca and cicatricial conjunctivitis. Ocular GVHD may lead to severe
ocular surface disease, which can significantly diminish quality of life and restrict
daily activities. It is thus important to monitor the condition closely since with timely
diagnosis, irreversible damage can be avoided. The current review will focus on updated information regarding ocular GVHD.
Keywords :
Allogeneic Stem Cell Transplantation , Bone Marrow Transplantation , Ocular Graft Versus Host Disease , Dry Eye , Keratoconjunctivitis Sicca
