Author/Authors :
Sharifzadeh, Mohammad Department of Pharmacology and Toxicology - Faculty of Pharmacy - Tehran University of Medical Sciences, Tehran, Iran , Ranjbar, Akram Department of Toxicology and Pharmacology - School of Pharmacy - Hamadan University of Medical Sciences, Hamadan, Iran , Hosseini, Asieh Razi Drug Research Center - Iran University of Medical Sciences, Tehran, Iran , Khanavi, Mahnaze Department of Pharmacogenosy - Faculty of Pharmacy - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
Diabetes mellitus is associated with distribution of cognitive functioning. Hyperglycemia
induced oxidative stress has been proposed as a cause of memory complications of diabetes
including cognitive impairment. The aim of this study was to examine total green tea extract
(TGTE), a potent free radical scavenger against spatial impairment in Streptozotocin-diabetic
rats. Eight weeks after diabetes induction, TGTE was administrated throught drinking water 3
mg/L. The learning and memory behavior was evaluated with Morris water maze task in male
rats. Then, for estimation of oxidative stress parameters such as lipid peroxidation (LPO), total
antioxidant capacity (FRAP) and total thiol groups in blood were measured. The total green tea
extract showed improved cognitive impairment in diabetic groups but these changes weren’t
significant. There was also significant increase FRAP level and total thiol groups in treated
green tea groups vs. control. group. This study demonstrated the effectiveness of TGTE on
spatial impairment and oxidative stress induced in diabetes mellitus.
Keywords :
Learning , Diabetes , Oxidative stress , Green tea , Spatial memory
