Author/Authors :
Pesaran Seiied Bonakdara, Ahmad Department of Chemistry - Shahreza Branch Islamic Azad University, Shahreza, Iran , Vafaeib, Farzane Department of Pharmacy - Shahreza Branch Islamic Azad University, Shahreza, Iran , Farokhpour, Mahbobeh Department of Pharmacy - Shahreza Branch Islamic Azad University, Shahreza, Iran , Nasr Esfahani, Mohammad Hossein Royan Institute - Isfahan branch , Massah, Ahmad Reza Department of Chemistry - Shahreza Branch Islamic Azad University, Shahreza, Iran
Abstract :
Today Cancer remains to be one of the most deadly diseases in the world. Due to the
potential anticancer activity of the chalcone and sulfonamide moieties, five novel hybrid
compounds containing both structures have been designed and synthesized in 3 steps. The
synthesized compounds were established on the basis of IR, 1H NMR, 13C NMR spectral data,
and elemental analysis and also they were screened for in-vitro anticancer activity on human
breast cancer cell line MCF-7. Among them, (E)–2–methoxy–N–(4–methoxyphenyl)–5–(3–
(4–nitrophenyl) acryloyl) benzene sulfonamide (4) showed the most potent anticancer activity
against MCF-7 cell line.
