Author/Authors :
Foroughifar, Naser Department of Chemistry - Tehran North Branch Islamic Azad University, Tehran, Iran , Karimi Beromi, Somayeh Department of Chemistry - Tehran North Branch Islamic Azad University, Tehran, Iran , Pasdar, Hoda Department of Chemistry - Tehran North Branch Islamic Azad University, Tehran, Iran , Shahi, Masoumeh Department of Chemistry - Tehran North Branch Islamic Azad University, Tehran, Iran
Abstract :
Heterocyclic compounds containing a pyrimidine nucleus are of special interests thanks
to their applications in medicinal chemistry as they are the basic skeleton of several bioactive
compounds such as antifungal, antibacterial, antitumor and antitubercular. As a part of our
research in the synthesis of pyrimidine derivatives containing biological activities, some new
tetrahydropyrimidine derivatives (1-10) were synthesized via Biginelli reaction using HCl or
DABCO as a catalyst with good yields. All structures of products were confirmed by IR, 1H
NMR and 13C NMR spectroscopy. The antibacterial activity of some synthesized compounds
was investigated against Staphylococcus aureus (ATCC 6538), Staphylococcus epidermidis
(ATCC 12228), Bacillus cereus (ATCC14579), Esherichia coli (ATCC 25922), Klebsiella
pneumonia (ATCC 13883) and Pseudomonas aeruginosa (PAO1) bacteria. Some of these
compounds such as 8 and 10 exhibited a good to significant antibacterial activity.
