Author/Authors :
Sifaoui, Ines Laboratoire Matériaux-Molécules et Applications - IPEST - University of Carthage, Tunisia , Lopez-Arencibia, Atteneri University Institute of Tropical Diseases and Public Health - University of La Laguna - Avda Francisco Sanchez s/n - Campus de Anchieta - 38271 La Laguna Tenerife, Canary Islands, Spain , Martín-Navarro, Carmen M University Institute of Tropical Diseases and Public Health - University of La Laguna - Avda Francisco Sanchez s/n - Campus de Anchieta - 38271 La Laguna Tenerife, Canary Islands, Spain , Reyes-Batlle, Maria University Institute of Tropical Diseases and Public Health - University of La Laguna - Avda Francisco Sanchez s/n - Campus de Anchieta - 38271 La Laguna Tenerife, Canary Islands, Spain , Mejri, Mondher Laboratoire Matériaux-Molécules et Applications - IPEST - University of Carthage, Tunisia , Valladares, Basilio University Institute of Tropical Diseases and Public Health - University of La Laguna - Avda Francisco Sanchez s/n - Campus de Anchieta - 38271 La Laguna Tenerife, Canary Islands, Spain , Lorenzo-Morales, Jacob University Institute of Tropical Diseases and Public Health - University of La Laguna - Avda Francisco Sanchez s/n - Campus de Anchieta - 38271 La Laguna Tenerife, Canary Islands, Spain , Abderabba, Manef Laboratoire Matériaux-Molécules et Applications - IPEST - University of Carthage, Tunisia , Pinero, Jose Enrique University Institute of Tropical Diseases and Public Health - University of La Laguna - Avda Francisco Sanchez s/n - Campus de Anchieta - 38271 La Laguna Tenerife, Canary Islands, Spain
Abstract :
Leishmaniasis represents a serious threat to the health as one of the most important neglected
tropical diseases as designated by the World Health Organization. The disease is endemic in
82 countries, among them Tunisia is an indigenous area for cutaneous Leishmaniasis. In a
previous work, two tritepenic acids namely oleanolic and maslinic acids have been isolated
from olive leaf extract. In the present paper, the in vitro activity against amastigotes stage of
Leishmania (L.) infantum and Leishmania (L.) amazonensis was investigated. Maslinic acid
showed the highest activity, against L. amazonensis, with an IC50 of 1.417 ± 0.401 μg/mL and
a selectivity index of 9.405. Although, the oleanolic acid exhibit a better activity against L.
infantum with an IC50 of 0.999 ± 0.089 μg/mL and selectivity index of 8.111.
Keywords :
Selectivity index , Anti-amastigotes activity , Triterpenic acids , Maslinic acid , Oleanolic acid
