• Title of article

    Sinapic Acid Derivatives as Potential Anti-Inflammatory Agents: Synthesis and Biological Evaluation

  • Author/Authors

    Zhang, Qiongyu Department of Basic Medical Science - Yongzhou Vocational Technical College, Yong Zhou 425100, PR China , Hu, Jun-Xiao Department of Basic Medical Science - Yongzhou Vocational Technical College, Yong Zhou 425100, PR China , Kui, Xu Department of Basic Medical Science - Yongzhou Vocational Technical College, Yong Zhou 425100, PR China , Liu, Chao Department of Anatomy and Neurobiology - Biology Postdoctoral Workstation - Basic School of Medicine Central South University, Changsha, Hunan, 410013, China , Zhou, Hui Tumor Hospital Xiangya School of Medicine of Central South University, Changsha, Hunan, 410013, China , Jiang, Xiaoxin Department of Anatomy and Neurobiology - Biology Postdoctoral Workstation - Basic School of Medicine Central South University, Changsha, Hunan, 410013, China , Zeng, Leping Department of Anatomy and Neurobiology - Biology Postdoctoral Workstation - Basic School of Medicine Central South University, Changsha, Hunan, 410013, China

  • Pages
    10
  • From page
    1405
  • To page
    1414
  • Abstract
    Transcription factor NF-κB and relevant cytokines IL-6 and IL-8 play a pivotal role in the pathogenesis of inflammation. Sinapic acid is a natural product and was demonstrated to possess anti-inflammatory activity. In this paper, we synthesized a series of sinapic acid derivatives and evaluated their anti-inflammatory effects. The result suggested that all of the targets compounds 7a-j inhibit NF-κB activation and decrease IL-6 and IL-8 expression in BEAS- 2B cells. By our biological assays, we found that all of the prepared compounds displayed stronger anti-inflammatory activities than their precursor sinapic acid. Especially, compounds 7g and 7i, with electron-drawing groups (nitro and fluoro moieties) in the benzimidazole ring, exhibited remarkable anti-inflammation activity, which was even stronger than the reference drug dexamethasone.
  • Keywords
    Interleukin , Nuclear factor-kappa B , Inflammation , Sinapic acid
  • Journal title
    Astroparticle Physics
  • Serial Year
    2017
  • Record number

    2416494

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2416494