Title of article :
Anti-oxidant and Anti-Inflammatory Cyclic Diarylheptanoids from Alnus japonica Stem Bark
Author/Authors :
Ibrahim, Sabrin R.M. Department of Pharmacognosy and Pharmaceutical Chemistry - College of Pharmacy - Taibah University, Al Madinah Al Munawarah 30078, Saudi Arabia , Mohamed, Gamal A. Department of Natural Products and Alternative Medicine - Faculty of Pharmacy - King Abdulaziz University, Jeddah, Saudi Arabia , Khedr, Amgad I. M Department of Pharmacognosy - Faculty of Pharmacy - Port Said University, Port Said 42526, Egypt , Aljaeid, Bader M Department of Pharmaceutics and Industrial Pharmacy - Faculty of Pharmacy - King Abdulaziz University, Jeddah 21589, Saudi Arabia
Abstract :
A new cyclic diarylheptanoid namely alnuheptanoid B (3), along with four known cyclic
diarylheptanoids: myricanone (1), (+)-S-myricanol (2), myricanone 5-O-β-D-glucopyranoside
(4), and (+)-S-myricanol 5-O-β-D-glucopyranoside (5) were isolated from the EtOAc fraction
of Alnus japonica Steud (family: Betulaceae) stem bark. Their structures were established by
different spectroscopic analyses, as well as optical rotation measurement. Compounds 1, 2, 4,
and 5 are isolated for the first time from A. japonica. The antioxidant and anti-inflammatory
activities of compounds (1-5) were assessed using DPPH assay and carrageenin induced rat
paw edema model, respectively. They displayed significant antioxidant activity in relation to
propyl gallate (standard antioxidant) at concentration 50 μM. Compound 2 demonstrated antiinflammatory
effect at a dose 10 mg/kg compared with indomethacin (positive control).
Keywords :
Antiinflammatory , Antioxidant , Cyclic diarylheptanoid , Alnuheptanoid B , Alnus japonica
Journal title :
Astroparticle Physics
