Title of article :
Evaluation of Tigecycline Activity Against Methicillin-Resistante Staphylococcus aureus Isolated from Biological Samples
Author/Authors :
Khalili, Hossein Department of Clinical Pharmacy - School of Pharmacy - Tehran University of Medical Sciences , Dashti-Khavidaki, Simin Department of Clinical Pharmacy - School of Pharmacy - Tehran University of Medical Sciences , Maleki, Zohreh department of Pathology - Valiasr laboratory - Imam Khomini Hospital , Khaleghi, Shahryar Department of Clinical Pharmacy - School of Pharmacy - Tehran University of Medical Sciences , Rasoolinejad, Mehrnaz Department of Infectious Diseases - School of Medicine - Tehran University of Medical Sciences
Abstract :
Tigecycline is a new glycylcycline antibiotic structurally similar to minocycline antibiotic. It has broad spectrum activity, including Staphylococcus aureus infections. This is the first study that evaluated the activity of Tigecycline against Staphylococcus aureus isolated from biological samples in Iran. In vitro activity of tigecycline against 160 Staphylococcus aureus including 99 methicillin-resistant S. aureus and 61 methicillin-susceptible S. aureus from inpatients at Imam Khomeini Hospital, Tehran, Iran was assessed. Bacterial susceptibility tests were performed by the disk diffusion method and also E-test for methicillin-resistant S. aureus isolates. All isolated had inhibition zone of ≥ 19 mm, with the minimum inhibitory concentration 50 (MIC50) and MIC90 of 0.19 and 0.5 μg/mL, respectively. The study results indicated that all methicillin-resistant S. aureus and methicillin-susceptible S. aureus isolates were susceptible to tigecyclin
Keywords :
Tigecycline , Staphylococcus aureus , Susceptibility pattern , MIC , Disk diffusion
Journal title :
Astroparticle Physics
