Title of article :
Antidepressant-like Effect of a Chalcone Compound, DHIPC and Its Possible Mechanism
Author/Authors :
Zhao, Dong-Hai Department of Pathology - Jilin Medical University, Jilin, Jilin Province 132013, P. R. China , Wang, Yan-Chun Department of Pathology - Jilin Medical University, Jilin, Jilin Province 132013, P. R. China , Zhengb, Lian-Wen Department of Obstetrics and Gynecology - Second hospital - Jilin University, Changchun 130041, P. R. China , Liu, Bing-Yu Food and Pharmacy College - Zhejiang Ocean University, Zhoushan, Zhejiang, 316022, P. R. China , Guan, Li-Ping Food and Pharmacy College - Zhejiang Ocean University, Zhoushan, Zhejiang, 316022, P. R. China
Pages :
9
From page :
193
To page :
201
Abstract :
DHIPC (2,4-dichloro-2´-hydroxyl-4´,6´-diisoprenyloxychalcone) is a new chalcone compound. In this study, its antidepressant-like activity of compound DHIPC was evaluated by the forced swimming test and the tail suspension test in mice. The results showed that DHIPC significantly reduced the immobility time for 2 h after treatment through the oral administration at dose of 10, 20, and 30 mg/kg in the forced swimming test and the tail suspension test, indicating a significant antidepressant-like effect. The maximal effect was obtained at 30 mg/ kg, which is similar to the positive control fluoxetine. The main monoamine neurotransmitters and their metabolites in rat brain were also simultaneously determined. It was found that DHIPC significantly increased the concentrations of the main neurotransmitters serotonin and noradrenalin, and also significantly increased 5-hydroxyindoleacetic acid contents in hippocampus, hypothalamus, and cortex in brain part. So, the probable mechanism of action of DHIPC is thought to be related to increase in serotonin and noradrenalin in the brain.
Keywords :
Neurotransmitters , Tail suspension test , Forced swimming test , Antidepressant-like activity , DHIPC , Chalcone
Journal title :
Astroparticle Physics
Serial Year :
2018
Record number :
2416730
Link To Document :
بازگشت