Author/Authors :
Foroughmand, Ali Mohammad Dept. of Genetics - Shahid Chamran University & Dept. of Psychiatrics - Jondishapour Medical University of Ahwaz. Ahvaz, Iran , Haidari, Maryam Dept. of Genetics - Shahid Chamran University & Dept. of Psychiatrics - Jondishapour Medical University of Ahwaz. Ahvaz, Iran , Galehdari, Hamid Dept. of Genetics - Shahid Chamran University & Dept. of Psychiatrics - Jondishapour Medical University of Ahwaz. Ahvaz, Iran , Pooryasin, Atefeh Dept. of Genetics - Shahid Chamran University & Dept. of Psychiatrics - Jondishapour Medical University of Ahwaz. Ahvaz, Iran , Kazeminejad, Reza Dept. of Genetics - Shahid Chamran University & Dept. of Psychiatrics - Jondishapour Medical University of Ahwaz. Ahvaz, Iran , Hosseini, Shiva Dept. of Genetics - Shahid Chamran University & Dept. of Psychiatrics - Jondishapour Medical University of Ahwaz. Ahvaz, Iran , Khajeh-Mogehi, Nahid Dept. of Genetics - Shahid Chamran University & Dept. of Psychiatrics - Jondishapour Medical University of Ahwaz. Ahvaz, Iran
Abstract :
Background: The disrupted-in-schizophrenia 1 (DISC1) gene, on the chromosome
position 1q42, was initially identified at the breakpoint of a balanced translocation,
t(1,11)(q42.1;q14.3), which segregated with major mental disorders in a large
Scottish family.
Methods: Our samples included 200 unrelated patients diagnosed with Schizophrenia
on the basis of DSM-IV criteria and 200 normal controls, which were gathered
from Iran. The allele and genotype frequencies of the polymorphism were determined
using Polymerase Chain Reaction-Restricted Fragment Length Polymorphism
(PCR-RFLP) and the data were analyzed by Logistic Regression test.
Results: In this study we genotyped the rs821616 polymorphism (Serin704Cystein)
located within exon 11 of the DISC1 gene. The samples were matched on the basis
of sex and ethnicity. We used the case control study to determine the possible association
between the ser704cys (rs821616) polymorphism and Schizophrenia. Analysis
of data in the samples, revealed no association between the rs821616 polymorphism
and Schizophrenia (OR= 0.697, 95% CI= 0.47-1.033, P=0.072).
Conclusion: In this study we did not find any association between the rs821616
SNPand schizophrenia.
Keywords :
single nucleotide polymorphism , rs821616 , DISC1 gene , schizophrenia , association study
