Title of article :
Synthesizing and Characterizing Functionalized Short Multiwall Carbon Nanotubes with Folate, Magnetite and Polyethylene Glycol as Multitargeted Nanocarrier of Anti-cancer Drugs
Author/Authors :
Jafari, Mahmoud Department of Physics - K. N. Toosi University of Technology, Tehran , Heidari, Danial Department of Physics - K. N. Toosi University of Technology, Tehran - Department of Pharmaceutics - Faculty of Pharmac - Mazandaran University of Medical Sciences, Sari , Ebrahimnejad, Pedram Department of Pharmaceutics - Faculty of Pharmacy - Mazandaran University of Medical Sciences, Sari - Pharmaceutical Sciences Research Center - Mazandaran University of Medical Sciences, Sari
Abstract :
Multifunctional nanomaterials showed great advantages in drug delivery. Folic acid
(FA) binding protein, a glycosyl phosphatidyl inositol anchored cell surface receptor for
folate, is overexpressed in several human tumors, whereas it is highly restricted in normal tissues. Therefore, in this study, FA, polyethylene glycol (PEG), and Fe3O4 nanoparticles multifunctionalized short multiwall carbon nanotubes (PEG-FA- SMWCNT@Fe3O4) were synthesized by conjugating folate, PEG, and magnetite nanoparticles with carboxylated multiwall carbon nanotubes. The prepared c-SMWCNT@Fe3O4 was characterized by X-ray diffraction (XRD) and vibrating sample magnetometer (VSM) in order to investigate crystal and magnetic properties, respectively. The images obtained by scanning electron microscopy (SEM)
showed that the magnetite nanoparticles were attached to the surfaces of carbon nanotubes and SMWCNT@Fe3O4 was formed. Investigation of functional groups using Fourier transform infrared (FTIR) spectra indicated that PEG-FA was successfully linked to SMWCNT@Fe3O4.
Keywords :
Carbon Nanotubes , Multi Function , Nanotechnology , Targeting
Journal title :
Astroparticle Physics
