Author/Authors :
Rabiee, Behnam Gastrointestinal and Liver Disease Research Center - Firoozgar Hospital - Iran University of Medical Sciences, Tehran , Roozafzai, Farzin Gastrointestinal and Liver Disease Research Center - Firoozgar Hospital - Iran University of Medical Sciences, Tehran , Hemasi, Gholam Reza Gastrointestinal and Liver Disease Research Center - Firoozgar Hospital - Iran University of Medical Sciences, Tehran , Poustchi, Hossein Liver and Pancreatobiliary Diseases Research Center - Digestive Diseases Research Institute - Shariati Hospital - Tehran University of Medical Sciences , Keyvani, Hossein Department of Virology - Tehran University of Medical Sciences , Khonsari, Mahmood Reza Gastrointestinal and Liver Disease Research Center - Firoozgar Hospital - Iran University of Medical Sciences, Tehran , Ajdarkosh, Hossein Gastrointestinal and Liver Disease Research Center - Firoozgar Hospital - Iran University of Medical Sciences, Tehran , Maadi, Mansooreh Gastrointestinal and Liver Disease Research Center - Firoozgar Hospital - Iran University of Medical Sciences, Tehran , Sima Saeedian, Fatemeh Gastrointestinal and Liver Disease Research Center - Firoozgar Hospital - Iran University of Medical Sciences, Tehran , Zamani, Farhad Gastrointestinal and Liver Disease Research Center - Firoozgar Hospital - Iran University of Medical Sciences, Tehran
Abstract :
BACKGROUND Type II diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD) are important causes of morbidity and mortality worldwide. We aimed to estimate the prevalence of DM in the context of NAFLD. METHODS In this cross-sectional study, we studied 5052 participants, aged 18 years and older, of a baseline
population-based cohort in northern Iran (N=6143). The prevalence of DM was estimated in individuals with and without NAFLD. The association between NAFLD and T2DM was evaluated using logistic regression with the adjustment of confounding effects of age, sex, body mass index, lipid profiles, and fasting insulin. RESULTS
In men, the prevalence (95% confidence interval) of T2DM was 5.34% (4.35%-6.34%) and 15.06% (13.12%-17.00%) in individuals without and with NAFLD, respectively (p <0.001). In women without NAFLD, the prevalence was 8.27% (6.83%-9.71%) while in the presence of NAFLD, the prevalence was 27.21% (24.59%-29.83%), (p <0.001). In univariate analysis, the chance of having
T2DM was 3.700 (3.130-4.380) times more in patients with NAFLD compared with subjects without NAFLD (p<0.001). This chance was reduced (Odds Ratio=1.976, 95% CI: 1.593-2.451, p <0.001) after removing the effects of other variables. CONCLUSION The prevalence of T2DM is increased in the context of NAFLD. This condition may be considered as an independent predictor of T2DM.
Keywords :
Non-alcoholic fatty liver disease , Diabetes mellitus , Non-communicable disease , Prevalence , Iran
