Author/Authors :
Nikbakht Dastjerdi, Mehdi Department of Anatomical Sciences and Molecular Biology - School of Medicine - Isfahan University of Medical Sciences, Isfahan, Iran , Momeni, Mohammad Immunology of Infectious Diseases Research Center - Rafsanjan University of Medical Sciences, Rafsanjan, Iran , Bidaki, Reza Department of Psychiatry - Research center for Addiction and Behavioral Sciences - Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Khaleghinia, Mehdi Kerman University of Medical Sciences, Kerman, Iran , Karimi-Googheri, Masoud Department of Immunology - Kerman University of Medical Sciences, Kerman, Iran , Kazemi Arababadi, Mohammad Immunology of Infectious Diseases Research Center - Rafsanjan University of Medical Sciences, Rafsanjan, Iran , Shabanizadeh, Ahmad Department of Anatomy - Faculty of Medicine - Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Abstract :
Background: Toll- like receptors (TLRs) play an important role in the recognition of DAMPs and
PAMPs and induction of inflammation. Previous studies demonstrated that depression and anxiety
can influence the expression levels of immune related molecules. Our previous study revealed that
mRNA levels of IRAKIRAK4, TRAF3 and IRF7 were significantly decreased in chronic HBV infected
(CHB) patients when compared to healthy controls. Therefore, the aim of this study was to
evaluate the effects of depression and anxiety on the expression levels of these molecules in CHB
patients.
Methods: Sixty CHB patients participated in this study and filled out the standard questionnaires;
and the expression of IRAK4, TRAF3 and IRF7 were examined using Real-Time PCR techniques.
Results: The results of this study demonstrated that expression of IRAK4, TRAF3 and IRF7 did not
differ between patients with various stages of depression and anxiety (all p>0.05).
Conclusion: According to the results, it seems that declined expression of IRAK4, TRAF3 and
IRF7 in CHB patients were not related to depression and anxiety, and other factors including genetic
and immunoregulatory effects of HBV may be responsible for the declined expression of these molecules.
Keywords :
IRF7 , TRAF3 , IRAK4 , Chronic HBV infection , Anxiety , Depression
