Author/Authors :
Zamani, Mohammad-Ali Department of Pediatrics - Shahrekord University of Medical Sciences, Shahrekord, Iran , Movahhedi, Mehran Department of Pediatrics - Shahrekord University of Medical Sciences, Shahrekord, Iran , Nourbakhsh, Mohammad-Kazem Department of Pediatrics - Tehran University of Medical Sciences, Tehran, Iran , Ganji, Forouzan Department of Community Medicine - Shahrekord University of Medical Sciences, Shahrekord, Iran , Rafieian-Kopaei, Mahmoud Medical Plants Research Center - Shahrekord University of Medical Sciences, Shahrekord, Iran , Mobasheri, Mahmoud Department of Epidemiology - Shahrekord University of Medical Sciences, Shahrekord, Iran , Khoshdel, Abolfazl Department of Pediatrics - Shahrekord University of Medical Sciences, Shahrekord, Iran , Etemadifar, Shahram Department of Nursing - Shahrekord University of Medical Sciences, Shahrekord, Iran , Shirani, Majid Department of Surgery - Shahrekord University of Medical Sciences, Shahrekord, Iran , Keivani Hafshejani, Zahra Shahrekord University of Medical Sciences, Shahrekord, Iran
Abstract :
Background: Complications of Ventolin as the most common drug used for bronchiolitis are widely
known. The present study was conducted to determine the efficacy of hypertonic saline 3%, compared
with Ventolin, for treatment of acute bronchiolitis in children.
Methods: This double-blinded clinical trial study was conducted in Hajar Hospital, Shahrekord,
Iran, from 2011 to 2012. A total of 70 patients under the age of two years with bronchiolitis were
divided into two groups of 35 each. Ventolin nebulizer and hypertonic saline 3% nebulizer three
times per day were administered in the first (Ventolin) and second (Hypersaline) group, respectively.
The length of recovery was compared between the two groups. The data were analyzed by SPSS
software (version 22) using chi-square, t-test, paired t-test, and Mann-Whitney.
Results: The mean±SD length of recovery was 4.14±0.9 and 3.06±0.6 in the Ventolin and hypersaline
groups, respectively. The mean duration of recovery was significantly lower in the hypersaline
group (p<0.001).
Conclusion: Hypertonic saline 3% nebulizer has more pleasant therapeutic effects on acute bronchiolitis
than Ventolin. Therefore, use of hypertonic saline 3% nebulizer is recommended for the
treatment of acute bronchiolitis in children under two years old.
Keywords :
Ventolin-albuterol , Bronchiolitis , Pediatric , Hypertonic saline solution
