Title of article
Role of MicroRNAs in Pathophysiology of Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis
Author/Authors
Iravani, Farzaneh MSc of human genetics - Department of Medical Genetics - Mashhad University of Medical Sciences, Mashhad , Hosseini, Neda MSc of Molecular and Cellular biology - Medical Genetics Research Center - School of Medicine - Mashhad University of Medical Sciences, Mashhad , Mojarrad, Majid Assistant Professor of Medical Genetics - Medical Genetics Research Center - School of Medicine - Mashhad University of Medical Sciences, Mashhad
Pages
7
From page
213
To page
219
Abstract
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide. It includes wide range of diseases from different subtypes of simple steatosis to non-alcoholic steatohepatitis (NASH), which may be complicated by liver fibrosis, cirrhosis, or hepatocellular carcinoma. Of the epigenetic factors that play a key role in the progression of it, is microRNAs (miRNAs). MiRNAs are short non-coding RNAs of 22-23 nucleotides in length, which regulate a large number of genes that have a critical role in regulation of lipid and cholesterol biosynthesis in hepatocytes. MiRNAs can be used as a very powerful biomarker to diagnosis and follow-up any
disorder, such as NAFLD and NASH with a high specificity and sensitivity. The aim of this study was to review the role of different miRNAs in the pathophysiology of NASH and NAFLD.
Keywords
MicroRNAs , NAFLD , NASH , Biomarker
Journal title
Astroparticle Physics
Serial Year
2018
Record number
2417574
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