Title of article :
Is the serum ferritin level a considerable predictor for hemorrhagic transformation of ischemic stroke?
Author/Authors :
Mehrpour, Masoud Department of Neurology - Firoozgar Hospital - Firoozgar Clinical Research Development Center (FCRDC) - Iran University of Medical Sciences, Tehran, Iran , Mehrpour, Mohammad Iran University of Medical Sciences, Tehran, Iran
Abstract :
Background: Hemorrhagic Transformation (HT) of Ischemic Stroke (IS) is a detrimental complication. This
study investigated the association between serum ferritin level and HT in patients with massive IS of middle
cerebral artery.
Methods: Thirty patients with massive IS of middle cerebral artery were enrolled in this prospective cohort
study. They were divided into two groups based on the serum ferritin level, lower or greater than 164.1ng/ml at
the first 24 hours after admission. To investigate the incidence of HT in the two groups, we observed them for
two weeks.
Results: During the two- week observation, the incidence of HT was two persons (13.3%) in the group with
the serum ferritin level of lower than 164.1ng/ml, and eight persons (53.3%) in the other group. This difference
was statistically significant between the two groups (p=0.02). The relative risk of HT was 4 (95% CI: 1.012-
15.8) in the patients with massive IS of middle cerebral artery and the serum ferritin level greater than
164.1ng/ml.
Conclusion: This study revealed that the serum ferritin level greater than 164.1ng/ml in the first 24 hours after
admission is a reasonably important predictor for HT of IS. Conducting studies on factors affecting the serum
ferritin level are suggested.
Keywords :
Ferritin , Hemorrhagic Transformation , Stroke
Journal title :
Astroparticle Physics