Title of article
IL-4 mRNA Expression in Laryngeal Squamous Cell Carcinoma Patients with or without Lymph Node Involvement
Author/Authors
Amirazodi, Esmael Shiraz Institute for Cancer Research - School of Medicine - Shiraz University of Medical Sciences, Shiraz , Razmkhah, Mahboobeh Shiraz Institute for Cancer Research - School of Medicine - Shiraz University of Medical Sciences, Shiraz , Jaberipour, Mansoureh Shiraz Institute for Cancer Research - School of Medicine - Shiraz University of Medical Sciences, Shiraz , Hosseini, Ahmad Shiraz Institute for Cancer Research - School of Medicine - Shiraz University of Medical Sciences, Shiraz , Khademi, Bijan Department of ENT - School of Medicine - Shiraz University of Medical Sciences, Shiraz
Pages
4
From page
20
To page
23
Abstract
Background: Interleukin (IL)-4 is a member of T helper 2 (Th2) axis produced by T-lymphocytes and mast cells. It has been shown that IL-4 expression changes in tumor tissues. The main objective of this study is to investigate the expression of IL-4 mRNA in patients with Laryngeal Squamous Cell Carcinoma (LSCC) with or without lymph node involvement. Materials and Methods: mRNA expression of IL-4 in LSCC tissues were detected by quantative Real-Time PCR (qRT-PCR). Expression of IL-4 gene was compared between lymph node positive and negative patients with Squamous Cell Carcinoma of Larynx. Results: No statistically significant association was found in expression of IL-4 between lymph node positive and negative patients. Conclusion: It seems that IL-4 has no important effect on the involvement of lymph node in LSCC. However, to achieve a definite conclusion more investigations are certainly required.
Keywords
Cancer , Interleukin-4 , Lymph Node Metastasis , Larynx , T helper 2
Journal title
Astroparticle Physics
Serial Year
2014
Record number
2417883
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