Author/Authors :
Mirmalek, Abbas Department of Surgery - Islamic Azad University - Tehran Medical Sciences Branch, Tehran , Elhamkani, Fatemeh Tehran University of Medical Sciences and Health Services - Shariati Hospital, Tehran , Salimi Tabatabaee, Alireza Students’ Research Committee - Islamic Azad University - Tehran Medical Sciences Branch, Tehran , Mahmoodzadeh, Hossein Tehran University of Medical Sciences and Health Services - Shariati Hospital, Tehran , Parsa, Yekta Students’ Research Committee - Islamic Azad University - Tehran Medical Sciences Branch, Tehran , Yadollah-Damavandi, Soheila Students’ Research Committee - Islamic Azad University - Tehran Medical Sciences Branch, Tehran , Jangholi, Ehsan Young Researchers Club - Islamic Azad University - Tehran Medical Sciences Branch, Tehran
Abstract :
Human Epidermal growth factor Receptor-2 (HER-2) as a new prognostic and predictive factor has been believed as an essential measurement in breast carcinoma. About 280 articles were reviewed and 115 were referred in this review article on HER-2. HER-2 is an oncoprotein epidermal growth factor receptor produced by a so-called cell surface oncogene. Overexpression results in aggressive behavior, early metastasis to lymph nodes and distant areas, and poor prognosis in breast cancer. HER-2 seems to be a prognostic and predictive factor and must be considered in all breast cancer cases.
Keywords :
Breast Cancer , Human Epidermal growth factor Receptor-2 , Prognosis , HER-2 , Review
