Author/Authors :
Mehranfar, Sahar Department of Molecular Medicine - School of Advanced Medical Science - Tabriz University of Medical Science - Hematology and Oncology Research Center - Tabriz University of Medical Sciences - Students Research Committee - Tabriz University of Medical Sciences , Zeinali, Sirous Department of Molecular Medicine - Biotechnology Research Center - Pasteur Institute of Iran, Tehran - Kawsar Human Genetics Research Center - Kawsar Genomics Center, Tehran , Hosseini, Rana Department of Community Medicine - Faculty of Medicine - Orumiye University of Medical Science , Mohammadian, Mozhdeh Faculty of Paramedical Sciences - Mazandaran University of Medical Sciences, Sari , Akbarzadeh, Abolfazl Department of Medical Nanotechnology - Faculty of Advanced Medical Sciences - Tabriz University of Medical Sciences , Hosein Pour Feizi, Abbasali Hematology and Oncology Research Center - Tabriz University of Medical Sciences
Abstract :
In 1845, leukemia was known as a systemic illness; and it was more than 100 years later that the first report of a significant therapy for leukemia was published in 1948. Leukemia was known as a multifactorial disease rather than a single disease till 1900. In 1965, less than 1% of children with acute leukemia were predictable to have long-term survivors; today, approximately 80% of children and adolescents with acute lymphoblastic leukemia are cured, these achievements are due to the cooperative effort of researchers and physicians in the field. Despite this success, leukemia is still the leading cause of death globally. This review aims to elucidate the history of leukemia from the beginning of the 19th century when scientists defined unusual disorders of the blood cells, till present. Additionally, we tried to discuss the history of the diagnosis and treatment of leukemia with particular emphasis on acute leukemia.
