Title of article :
Drugs Induced Alzheimer’s Disease in Animal Model
Author/Authors :
Malekzadeh, Samira Department of Physiology - College of Sciences - Fars Science and Research Branch - Islamic Azad University - Department of Physiology - College of Sciences - Shiraz Branch - Islamic Azad University , Edalatmanesh, Mohammad Amin Department of Physiology - College of Sciences - Shiraz Branch - Islamic Azad University , Mehrabani, Davood Stem Cell and Transgenic Technology Research Center - Shiraz University of Medical Sciences , Shariati, Mehrdad Department of Biology - Kazerun Branch - Islamic Azad University
Abstract :
Alzheimer’s disease (AD) can be described by characteristics like dementia, mental and cognitive dysfunctions, and memory impairment. Nowadays, with progresses of science, attempts to treat many diseases have increased. Laboratory animals help to discover new ways of treating disease. AD induced by chemical drugs in animal models can be useful in better understanding the mechanisms of disease and treatment of AD. In recent decades, many researchers have reported transgenic rat models of AD but this modeling has a great problem and does not contain all kinds of AD. There are two types of AD, including familial (5% of all AD) and sporadic, but the transgenic model does not show the complete model of AD, especially in sporadic form of AD, which is 95% of AD cases. We decided to describe another modeling of AD using chemical drugs such as colchicine, scopolamine, okadaic acid, streptozotocin, and trimethyltin.
Keywords :
Alzheimer’s Disease , Hippocampus , Memory , Trimethyltin , Colchicine
Journal title :
Astroparticle Physics
