Nano selenium-lovastatin mixture modulate inflammatory cascade in arthritic irradiated model

Background: The development of nanotechnology has been a boon to mankind as its significance paved the way for several applicaons in therapeucs. This study was to evaluate the an-arthric capability of nano Selenium-lovastan mixture (Lov-Se) against inflammatory cascade in arthric irradiated rats. Materials and Methods: Animal model of Arthris was organized by subcutaneous injecon of Complete Freund’s adjuvant; CFA. Rats were exposed to γ-radiaon (2Gy every 3 days up to total dose of 8 Gy). Lov-Se (1ml ≈ 20 mg kg−1 day−1Lov and 0.1 mg kg−1 day−1Se) was administrated by daily oral injecon. The anoxidant parameters (heart glutathione peroxides; GSH-Px, catalase; CAT, superoxide dismutase; SOD, xanthine dehydrogenase; XDH, reduced glutathione; GSH and blood selenium; Se), oxidant markers (heart Xanthine oxidase; XO, Nitric oxide; NO, protein carbonyls and thiobarbituric acid reacve substances; TBARS) and the inflammatory molecules (serum tumor necrosis factor-alpha TNF-α, C-reacve protein; CRP and rheumatoid factor; RF) were determined. Results: The arthric and arthric irradiated rats were displayed augment oxidave stress, inflammatory cascade and impaired anoxidant status compared to control. Conclusion: The data revealed that Lov-Se administraon ameliorate oxidave, anoxidants parameters as well as inflammatory factors. The prolonged administraon of Lov-Se mixture in appropriate concentraon could exert a considerable systemic an-inflammatory acon through adjustment of red-ox tone and the integraon of XDH/XO rao.