Electrochemical Behavior of Antiemetic Drug Metoclopramide at Electrochemically Pre-treated Pencil Graphite Electrode

Highly economic and selective method for the analysis of dopamine-receptor antagonist and antiemetic drug Metoclopramide is developed. In this method Metoclopramide is analyzed electrochemically by using pre-treated pencil graphite electrode (PTPGE) by differential pulse and cyclic voltammetry. The PTPGE showed very good result with significant enhancement of the peak current. The dependence of the current on pH, concentration and scan rate was investigated to optimize the experimental conditions for determination of Metoclopramide. The oxidative peak current increased linearly with the concentration of Metoclopramide in the range of 1.0×10-8 to 1.3×10-6 M. The limit of detection was found to be 1.29×10-11 M. The pre-treated electrode showed good selectivity, reproducibility and stability for the detection of trace Metoclopramide. The proposed method was successfully applied to Metoclopramide determination in pharmaceutical formulations and real samples.