Title of article
Voltammetric Behavior of Isoniazid and Its Electroanalytical Determination at Carbon Nanotubes-CTAB Modified Glassy Carbon Electrode
Author/Authors
Buddanavar, Arunkumar T P.G. Department of Studies in Chemistry - Karnatak University , Gowda , Jayant I P.G. Department of Studies in Chemistry - Karnatak University , Nandibewoor, Sharanappa T P.G. Department of Studies in Chemistry - Karnatak University
Pages
16
From page
329
To page
344
Abstract
An electrochemical sensor for sensitive determination of isoniazid (INH) using multi-walled carbon nanotubes-cetyltrimethyl ammonium bromide (CTAB) surfactant composite on the surface of a glassy carbon electrode was developed. The peak current increased greatly compared with bare GCE and MWCNT/GCE electrode. The oxidation process was irreversible over pH range studied and exhibited a diffusion controlled behavior. The current response was found to be directly proportional to the concentration of INH in the concentration range of 1.0×10-7 M to 1.2×10-6 M with a limit of detection (LOD) of 2.14×10-9 M. The modified electrode showed good selectivity and reproducibility. The developed analytical method was successfully applied to isoniazid determination in human serum and urine samples. This method can be employed in clinical analysis, quality control and routine determination of drugs in pharmaceutical formulation.
Keywords
Isoniazid , Multi-walled carbon nanotubes , CTAB , Diffusion controlled , Real samples
Journal title
Astroparticle Physics
Serial Year
2016
Record number
2418675
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