Title of article :
Electroanalytical Determination of Atorvastatin in Pharmaceutical Formulations based on Edge-Plane Pyrolytic Graphite Electrode
Author/Authors :
Fazlolahzadeh, Omid Department of Chemistry - Faculty of Sciences - K.N. Toosi University of Technology , Rouhollahi, Ahmad Department of Chemistry - Faculty of Sciences - K.N. Toosi University of Technology , Hadi, Mojtaba Department of Chemistry - Faculty of Sciences - University of Qom
Abstract :
An electrochemical sensor employing edge-plane pyrolytic graphite electrode (EPPGE), without any need for surface pretreatment or surface chemical modification, for the sensitive detection of atorvastatin (AT) are reported using voltammetric techniques. The results indicated that EPPGE remarkably enhanced the electro-oxidation of AT, which led to enhanced peak currents and decrease in peak potentials to less positive values. Compared with basal-plane pyrolytic graphite electrode (BPPGE) and glassy carbon electrode (GCE), EPPGE showed better electrochemical responses both in terms of sensitivity and detection limit. The repeatability of the responses was found good and the method was applied successfully for sensing of AT in pharmaceutical formulations with good recoveries
Keywords :
Atorvastatin electro-oxidation , Basal-plane pyrolytic graphite , Edge-plane pyrolytic graphite
Journal title :
Astroparticle Physics
