The Simultaneous Electrochemical Determination of Dopamine and Uric acid at Ni0.02Sn0.98O2 Nanoparticles Modified Carbon Paste Electrode by Cyclic Voltammetric Technique

The electrochemical method using Ni0.02Sn0.98O2 nanoparticles modified carbon paste electrode (NSNMCPE) for the determination of dopamine (DA) and uric acid (UA). The Ni0.02Sn0.98O2 nanoparticles were synthesized by gel combustion method. These synthesized Ni0.02Sn0.98O2 nanoparticles were characterized by XRD and SEM. Then the carbon paste electrode is modified with the synthesized Ni0.02Sn0.98O2 nanoparticles by grinding method. The surface morphology of NSNMCPE was confirmed by SEM. The NSNMCPE was successfully used to study the electrochemical investigation of DA and UA in 0.1 M phosphate buffer solution (PBS) of pH 7.0 and pH 6.0 by cyclic voltammetric technique (CV). The low detection limit (LOD) of DA and UA were found to be 0.831×10-5 M and 1.11×10-5 M and the low quantification limit (LOQ) of DA and UA were 2.77×10-6 M and 0.371×10-6 M respectively. The NSNMCPE was used for the simultaneous determination of DA and UA, the separation of the overlapping voltammograms of dopamine and uric acid at modified electrode in a mixture is successfully carried by using cyclic voltammetric technique. The proposed method was successfully applied for the determination of DA and UA due to its good sensitivity, lower detection limit and ease of preparation of the NSNMCPE allows the development of a highly sensitive voltammetric sensor for the determination of DA and UA