Novel Electrochemical Sensor based on ZrO2 Nanoparticles Modified Glassy Carbon Electrode for low-trace Level Determination of Amlodipine by Differential Pulse Voltammetry

A fast and selective electrochemical sensor for determination of amlodipine was developed based on ZrO2 nanoparticles modified glassy carbon electrode. Amlodipine could be determined directly by electrochemical oxidization with the modified electrode. ZrO2 nanoparticles increased electrochemical response to amlodipine. Experimental variables, such as the deposited amount of the modifier suspension, pH of the supporting electrolyte and the potential scan rate were optimized by monitoring the electrochemical responses of amlodipine. Under the optimum conditions, the modified electrode showed a wide linear dynamic range of 10.0–200.0 μM with a detection limit of 2.0 μM for the voltammetric determination of amlodipine. The prepared modified electrode showed high sensitivity, stability and good reproducibility in response to amlodipine, confirming its usability for the accurate determination of trace amounts of amlodipine in pharmaceutical and clinical preparations.