Coronary Artery Bypass Graft in Six Members of a Family: A Case Series

Coronary artery disease (CAD) is a multifactorial condition. Although hyperlipidemia (HLP), diabetes (DM), and hypertension (HTN) are known as familial and cardiac risk factors, coronary artery bypass graft (CABG) in several members of a family is rare. We reported the case of six members of a family who presented with myocardial infarction and/or advanced angina pectoris during six years. CABG was considered for all the patients due to involvement of the main coronary arteries and clinical presentations. Ejection fraction (EF) was varied between 25% and 70%. Beating heart cardiopulmonary bypass (beating heart CPB) and off-pump techniques were the surgical methods of choice. The mean duration of surgery was about 4 hours. The only post-operative complication was deep wound infection in a young man who was a smoker and drug abuser. Given the genetic relationship of the patients and the strong effect of genetic penetration, we presume the impact of genetics on the incidence of CAD and the probability of undergoing CABG in members of a specific family.