Title of article
Determination of Enalapril in Pharmaceuticals using Electrochemical Sensing with Amperometric Detection
Author/Authors
Mehmeti, Eda Institute of Chemistry – Analytical Chemistry - Karl-Franzens University Graz, Austria , Stanković, Dalibor M The Vinča Institute of Nuclear Sciences - University of Belgrade , Kalcher, Kurt Institute of Chemistry – Analytical Chemistry - Karl-Franzens University Graz, Austria
Pages
8
From page
1000
To page
1007
Abstract
In this work a new electrochemical method will be presented for the determination of enalapril in pharmaceutical tablets using unmodified screen printed electrode (SPE). The studies were done using amperommetric detection. Enalapril provides well defined, oval-shape oxidation peak at +1.05 V (vs. Ag/AgCl, 3.0 M KCl) in Britton-Robinson buffer solution (BRBS) at pH 5.0. After optimization of the experimental conditions, the influence of most common interferent compounds was tested. Under optimized experimental conditions, the signals were linearly proportional to the concentration of enalapril in the range from 2.5 to 90 μM with a detection limit of 0.9 μM. Repeatability of ten replicate measurements of 5 μM enalapril was estimated to be 1.5%. Proposed method was successfully applied for the determination of the total amount of enalapril content in pharmaceutical preparations. Nevertheless, proposed method could be beneficial for the quick quantifications of enalapril in drugs using unmodified SPE electrode without any further treatment.
Keywords
Enalapril , Pharmaceutical tablets , Screen printed electrode , Amperometry
Journal title
Astroparticle Physics
Serial Year
2017
Record number
2418846
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