Application of Graphite Screen Printed Electrode Modified with Indium(III) Mixed-ligand Nanocomplex for Voltammetric Determination of Amlodipine

The current work focuses on the development of a sensitive and selective electrochemical device based on a graphite screen printed electrode modified with indium(III) mixed-ligand nanocomplex (In(III) nanocomplex/SPE) for the analysis of amlodipine. The studies proved the sensor to have excellent electron-mediating behavior in the oxidation of amlodipine in a 0.1 M phosphate buffer solution (PBS) (pH 7.0), and the response of the sensor was found significantly depend on the charge and structure of the analyte. The detection limit of the method for amlodipine was 0.2 μM (S/N=3) and the response was found to be linear in the concentration range of 1.0 to 500.0 μM. The modified electrode was use for the detection of amlodipine in real samples and found to produce satisfactory results.