Effect of polycystic ovaries syndrome on outcome of assisted reproductive Technology in Isfahan Fertility-Infertility Center

Background: Polycystic ovaries syndrome (PCOS) is the most common disorder in infertile women with ovulation sterility. There are some instances of abnormal endocrine in the women stricken by this syndrome and so the clinical results of ovulating induction in them, because of severe response of ovary against ovulating induction, are very discussing and may lead to different results from those with normal ovary. In this research the effect of ovulating induction among this group of women was compared with the women with normal ovary and tubal sterility. Methods: This prospective cohort study performed on 260 infertile pairs with PCOS and tubal factors under treatment using fertility assistance techniques in IFIC. The numbers of oocyte, concentration of testosterone and andrestandion, fertility rate and embryo quality were compared. Results: The mean of oocyte retrieved, concentration of andrestandion in follicular and LH0 phases, and testosterone in LH0 phase were higher in PCOS patients (p < 0.05), but the fertilization rate indicated no difference between two groups. According to the results there was a significant association between the concentration of andrestandion and testosterone phase LH0 and the embryo quality. Conclusion: The ovulation induction in PCOS by increasing the serum androgen concentration would lead to undesirable influence on oocyte, so that the achieved embryo has a lower quality and the ratio of good-quality embryo decrease, but because of the high number of oocyte and the number of achieved embryo in the women with PCOS the chance of growing more good-quality embryo is high.